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Individualized Targeting and Neuromodulation of Late-Life Depression
Sponsor: University of New Mexico
Summary
An open-label, single-arm, clinical research study about how to make transcranial magnetic stimulation (TMS), an FDA-approved treatment, more effective for patients with late-life depression using fMRI.
Key Details
Gender
All
Age Range
60 Years - 79 Years
Study Type
INTERVENTIONAL
Enrollment
24
Start Date
2024-10-01
Completion Date
2026-07-01
Last Updated
2026-01-08
Healthy Volunteers
No
Conditions
Interventions
rTMS
rTMS will be delivered to the fMRI-determined DLPFC hotspot according to conventional parameters for clinical treatment (e.g., excitatory: 75 trains of 40 pulses, 10Hz, up to 3000 pulses). Magnetic field strength will be up to 120% of resting motor threshold. Ramp up of magnetic field strength may be utilized in the first week for tolerability. Side effects will be monitored and coil angle adjusted to improve tolerability if necessary.
Locations (1)
University of New Mexico HSC
Albuquerque, New Mexico, United States