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Oxytocin for Weight Loss in Adolescents
Sponsor: Massachusetts General Hospital
Summary
This is a randomized, double blind, placebo-controlled study of the effects of intranasal oxytocin in youths with obesity, ages 12-18 years old. Subjects will be randomized to receive intranasal oxytocin or placebo (1 spray per nostril, 4 times per day) for 12 weeks. Study visits include screening to determine eligibility, 2-part main study visits at baseline, week 8, and week 12, and safety check-in visits at weeks 1, and 4; phone calls at weeks 2, 6, and 10, with a safety follow-up visit 6 weeks after the last dose of study drug. Study procedures include appetite, behavioral, metabolic, and endocrine assessments.
Official title: Oxytocin as a Neuroendocrine Therapy for Obesity in Youth
Key Details
Gender
All
Age Range
10 Years - 18 Years
Study Type
INTERVENTIONAL
Enrollment
75
Start Date
2021-07-28
Completion Date
2027-03-31
Last Updated
2025-07-20
Healthy Volunteers
No
Conditions
Interventions
Oxytocin nasal spray
24 IU nasal spray, 4 times per day for 12 weeks
Placebo
24 IU nasal spray, 4 times per day for 12 weeks
Locations (1)
Massachusetts General Hospital
Boston, Massachusetts, United States