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Aquaporin-4 Single Nucleotide Polymorphisms in Patients With Idiopathic and Familial Parkinson's Disease
Sponsor: University of Exeter
Summary
The purpose of this study is to understand the relationship between problems in sleep, genetic variations in the Aquaporin-4 gene (AQP4), and the development of Parkinson's Disease.
Official title: Study on the Effects of Single Nucleotide Polymorphisms in Aquaporin-4 (AQP4) Gene on the Clinical Phenotype in Patients With Idiopathic and Familial Parkinson's Disease.
Key Details
Gender
All
Age Range
18 Years - 85 Years
Study Type
OBSERVATIONAL
Enrollment
800
Start Date
2018-11-28
Completion Date
2025-12-31
Last Updated
2025-10-07
Healthy Volunteers
No
Conditions
Interventions
Study procedure
All participants will undergo a collection of demographic data, personal and family history for PD, a neurological examination and administration of clinical scales. All participants will undergo a collection of venous blood sample. At the end of the visit they will receive a wristwatch to monitor their sleep at home (Actigraph) and a sleep diary, together with a prepaid envelope to post the watch and the diary back to the investigators. They will also receive a link for a series of online tests for non-motor symptoms related to Parkinson's disease that they can complete remotely at home.
Locations (4)
East Kent University Hospitals NHS Foundation Trust
Ashford, United Kingdom
University of Exeter
Exeter, United Kingdom
Prince Phillip Hospital
Llanelli, United Kingdom
Lewisham and Greenwich NHS Foundation Trust
London, United Kingdom