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Low-Intensity Focused Ultrasound Pulsation (LIFUP) for the Treatment of Generalized Anxiety Disorder (GAD)
Sponsor: University of California, Los Angeles
Summary
There are few treatment options available for patients once they have failed standard psychopharmacological therapy for generalized anxiety disorder. Existing brain stimulation methods such as rTMS fail to target deep brain structures associated with anxiety disorders; structures such as the amygdala. In this double-blind sham-controlled clinical trial, the investigators propose to establish baseline severity of anxiety in 48 patients, then deliver eight treatments over four sessions of focused ultrasound stimulation to the amygdala. Anxiety severity will be assessed using standard psychometric scales after each session, and at follow-ups.
Official title: Feasibility of Low-Intensity Focused Ultrasound Pulsation (LIFUP) for the Treatment of Generalized Anxiety Disorder (GAD)
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
48
Start Date
2021-07-26
Completion Date
2027-12
Last Updated
2026-02-10
Healthy Volunteers
No
Conditions
Interventions
Active LIFUP Treatment
8 LIFUP Treatments
Sham LIFUP Treatment
8 sham LIFUP treatments
Locations (3)
University of California, Los Angeles
Los Angeles, California, United States
Massachusetts General Hospital
Boston, Massachusetts, United States
Medical University of South Carolina
Charleston, South Carolina, United States