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Impact of Exercise on Mitochondria in Cancer Patients.
Sponsor: University of Nottingham
Summary
The aim is to investigate the impact of prostate and colorectal cancer on mitochondrial quantity and quality along with muscle mass and function and whether this can be modified through the use of a home-based short-term exercise training program. The investigators aim to recruit participants awaiting curative surgery for colorectal and prostate cancer and to assess the variation in baseline mitochondrial activity between them. Participants from both cancer types will then carry out a 4 week home exercise program, this will be randomly allocated to either resistance-based or high-intensity interval training based. Participants will then be re-assessed on the day of their planned surgical procedure to assess the changes effected by the training program. The investigators hypothesize that there will be variation in mitochondrial activity linked to muscle mass across the two cancer types and that home-based exercise programs have the ability to improve mitochondrial activity along with muscle mass.
Official title: The Impact of Short-term Exercise Programs on Mitochondrial Activity in Colorectal and Prostate Cancer Patients.
Key Details
Gender
All
Age Range
50 Years - Any
Study Type
INTERVENTIONAL
Enrollment
15
Start Date
2021-08-05
Completion Date
2024-03-30
Last Updated
2026-04-29
Healthy Volunteers
No
Conditions
Interventions
Resistance exercise training
Each session will be performed at home, with resistance bands used to provide resistance. Participants will be guided to increase the resistance if over 15 repetitions can be performed prior to fatigue. Weekly contact will be made with participants to encourage participation and to guide the exercise. Each session will include: 2 min warm-up jogging on the spot 2 sets of 12-15 repetitions of: Squats Hip flexion Hip extension Hip abduction Seated row Bench press Lateral raises 2 min jogging on the spot cooldown.
High-intensity interval training
Each session will include: * 2 min warm-up: jogging on the spot * Each of the following exercises performed for 60seconds, interspaced by 90 seconds rest * Star jumps * Standing squats * On-the-spot sprints * Standing squats * Star jumps * 2 min cool-down: jogging on the spot Participants will be contacted weekly to encourage participation and to guide the exercise
Locations (1)
Thomas Smart
Derby, Derbyshire, United Kingdom