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The Effects of IV vs Oral Dexamethasone on Postoperative Nausea, Vomiting, and Pain
Sponsor: University of Colorado, Denver
Summary
The hypothesis being tested in this study is that perioperative oral administration of dexamethasone, when compared to intravenous (IV) administration, offers a similar reduction in postoperative nausea and vomiting (PONV), and reduction in postoperative pain in pediatric patients undergoing tonsillectomy with or without adenoidectomy and/or tympanostomy tube placement. The specific aim of this study is to demonstrate non-inferiority of oral dexamethasone when compared to IV dexamethasone, given that there is currently a severe, sudden, and world-wide shortage of IV dexamethasone given its recent use in treating patients with covid19 disease.
Official title: The Effects of IV vs Oral Dexamethasone on Postoperative Nausea, Vomiting, Pain, and Drug Cost in Children Undergoing Tonsillectomy: A Randomized Controlled Prospective Non-inferiority Study
Key Details
Gender
All
Age Range
3 Years - 7 Years
Study Type
INTERVENTIONAL
Enrollment
126
Start Date
2020-10-23
Completion Date
2023-05-24
Last Updated
2026-08-28
Healthy Volunteers
No
Conditions
Interventions
dexamethasone
Prevention of post op nausea and vomiting
Locations (1)
Children's Hospital of Colorado
Aurora, Colorado, United States