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Advancing Prevention of Pulmonary Fibrosis
Sponsor: University of Colorado, Denver
Summary
This study plans to learn more about pulmonary fibrosis and how it develops. We want to determine if the disease can be detected early, before the lung is permanently scarred. This study will enroll participants who are not currently diagnosed with pulmonary fibrosis, but who have family members with pulmonary fibrosis. Because there is an increased risk within affected families, this cohort will allow us to learn how pulmonary fibrosis develops, and how the lungs change over time.
Official title: Advancing Prevention of Pulmonary Fibrosis - A Cohort Study of Preclinical Pulmonary Fibrosis
Key Details
Gender
All
Age Range
40 Years - 75 Years
Study Type
OBSERVATIONAL
Enrollment
800
Start Date
2021-01-22
Completion Date
2026-08-01
Last Updated
2025-03-25
Healthy Volunteers
Yes
Conditions
Interventions
Sample collection
Blood, Urine, Nail, Hair, Saliva, optional Stool
Questionnaires
SF-36, Food Frequency, Pulmonary Fibrosis Study questionnaire, COVID questionnaire
High resolution CT scan of the chest
Upon enrollment, all participants will undergo single prone volumetric thoracic chest CT scan. This will be performed at full inspiration using a 64-slice CT scanner.
Pulmonary Function Test
All recruited participants will undergo a pre-bronchodilator spirometry test and a lung diffusion capacity test, both in accordance with ATS guidelines. Exercise capacity (maximum physical exertion) will be assessed by performing a 6-minute walk test, also according to ATS guidelines.
Locations (1)
University of Colorado Anschutz Medical Campus
Aurora, Colorado, United States