Clinical Research Directory
Browse clinical research sites, groups, and studies.
Health Effects of Substituting Sugary Beverages With Artificially-sweetened Beverages or Water
Sponsor: Brigham and Women's Hospital
Summary
Sugar-sweetened beverages (SSBs) contribute an alarming \~7% of calories in the US diet among adults, making SSBs the single largest source of added sugar. However, whether artificially sweetened beverages are a healthful alternative for reducing SSB intake among habitual SSB consumers is unknown. Therefore, the investigators will conduct a 4-arm randomized diet intervention trial to test the effects of substituting SSBs with calorie-free alternatives on body weight and health, among habitual SSB consumers with overweight/obesity.
Official title: SUBstituting With Preferred Options: Health Effects of Substituting Sugar-sweetened Beverages With Non-caloric Beverages in Adults With Overweight and Obesity
Key Details
Gender
All
Age Range
20 Years - 69 Years
Study Type
INTERVENTIONAL
Enrollment
460
Start Date
2021-04-22
Completion Date
2026-03-01
Last Updated
2025-11-19
Healthy Volunteers
Yes
Conditions
Interventions
Maintain usual SSBs
Instruction/guidelines to maintain baseline intake of SSBs (months 0-6); then switch to water only (months 6-12)
Substitute to non-SSBs
Instruction/guidelines to eliminate SSBs and replace, where possible, with beverages consistent to group assignment (months 0-6); then switch to water only (months 6-12)
Study app
Engage with a motivational mobile app to track beverage intake and complete study data collection
Beverage delivery
Select from approved beverages for a monthly at-home delivery (months 0-6)
Locations (1)
Brigham and Women's Hospital
Boston, Massachusetts, United States