Clinical Research Directory

Inclusion Criteria: 1. Subject is ≥ 18 years of age 2. Subject has a primary indication and is scheduled for ICD implantation or replacement 3. Subject has heart failure NYHA Class II or III Exclusion Criteria: 1. Subject is to receive a single chamber defibrillator 2. Subject has an ejection fraction of 25% or less 3. Subject's systolic blood pressure is less than 120 mm Hg on the day of implant 4. Subject has decompensated heart failure 5. Subject has significant (\>2+) mitral regurgitation, aortic regurgitation or aortic stenosis. 6. Subject has permanent atrial fibrillation 7. Subject has atrial fibrillation on the day of the study. 8. Subject has hypertrophic cardiomyopathy, restrictive cardiomyopathy or interventricular septal thickness ≥15 mm 9. Subject has a history of prior neurological events (stroke or TIA) within the past year or a neurological event (stroke or TIA) at any prior time that has resulted in residual neurologic deficit. 10. Subject has a history of autonomic dysfunction 11. Women who are pregnant or breast-feeding 12. Subject cannot or is unwilling to provide informed consent.