Clinical Research Directory

MAST DURATION Inclusion Criteria: * Patients aged ≥10 years with TBI managed in an NSU who have started on an phenytoin or levetiracetam due to an acute symptomatic seizure during acute hospitalisation * Patient or Legal Representative is willing and able to provide informed consent or in the absence of a legal representative, an Independent Healthcare Professional provides authorisation for patient enrolment Exclusion Criteria: * Unsurvivable injury * Previous history of epilepsy * Patients who are on an AED pre-TBI * Patient who has been clinically prescribed an AED other than phenytoin or levetiracetam * Unwillingness to take products containing gelatin (animal products) * Severe lactose intolerance or any known hypersensitivity to study drug or any of its excipients MAST-PROPHYLAXIS Inclusion Criteria: * Patients aged ≥10 years, with TBI managed in an NSU without an acute symptomatic seizure * Patient or Legal Representative is willing and able to provide informed consent or in the absence of a legal representative, an Independent Healthcare Professional provides authorisation for patient enrolment within 48 hours of admittance. Exclusion Criteria: * Post-traumatic seizures * Unsurvivable injury * Previous history of epilepsy * Patients who are on an AED pre-TBI * Pregnancy or breastfeeding * Unwillingness to take products containing gelatin (animal products) * Severe lactose intolerance or any known hypersensitivity to study drug or any of its excipients * Time interval from the time of admission to NSU to randomisation exceeds 48 hours