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Role of Statins In Slowing Rheumatic Heart Disease (RHD) Progression
Sponsor: University of Washington
Summary
The goal of this study is to address specific implementation questions necessary and sufficient to ensure the feasibility of the larger randomized trial examining the efficacy of statin medications in slowing rheumatic heart disease (RHD) valvular pathology progression. This feasibility study is intended to confirm the number of readily recruitable subjects, assess recruitment rate, and assess the rate of valve pathology via echocardiograms. These results are necessary and sufficient to facilitate the successful design of a large full scale randomized trial to determine whether statins improve outcomes in RHD. Successful treatment of RHD would fundamentally shift the RHD management paradigm world-wide, improve the lives of millions afflicted with RHD, and subsequently, decrease health care spending on RHD management.
Official title: Role of Statins In Slowing Rheumatic Heart Disease (RHD) Progression: A Feasibility Study For A Randomized Controlled Trial
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
OBSERVATIONAL
Enrollment
100
Start Date
2022-02-08
Completion Date
2040-02
Last Updated
2023-06-05
Healthy Volunteers
No
Conditions
Interventions
Atorvastatin
Participants in the intervention arm will receive a pill packet with atorvastatin (40mg) x 18 months.
Placebo
Participants in the control arm will receive a pill packet with placebo x 18 months.
Locations (1)
Manmohan Memorial Medical College & Teaching Hospital.
Kathmandu, Nepal