Clinical Research Directory

Inclusion Criteria: For all subjects: * Informed consent as documented by signature * Diagnosis of PD based on the MDS clinical diagnostic criteria for Parkinson's disease * Fulfilling criteria for STN-DBS: * The presence of disabling motor complications of dopaminergic treatment * The absence of surgical contraindications * Planned bilateral STN-DBS using steering electrodes in the next 3 months (routine standard of care) Exclusion Criteria: * Presence of dementia as indicated by a score ≤ 25 on the MOntreal Cognitive Assessment (MOCA) * Depression with acute suicidal ideation * Presence of major ongoing psychiatric illness * Non-compensated systemic disease (i.e., diabetes, hypertension) * Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant * Participation in interventional trial within the 30 days preceding and during the present study * Previous enrolment into the current study * Enrolment of any study site personnel, their family members, employees or other dependent persons