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Hypofractionated External-beam RadiOtherapy for Intact Cervical Cancer (HEROICC-Trial): A Feasibility Study
Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Summary
External radiation given in 25 fractions or so together with weekly chemotherapy and followed by 3 or 4 fractions of brachytherapy is the standard of care for patients with locally advanced cervical cancer. This study investigates the role of shortened external radiotherapy regimen (hypofractionated radiotherapy) by randomizing patients to this experimental regimen versus the standard of care.The purpose of this study is to access the feasibility of patient accrual to this trial in the Canadian setting and to provide an initial evaluation of cancer response and treatment tolerability.
Key Details
Gender
FEMALE
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
48
Start Date
2021-02-04
Completion Date
2028-12-14
Last Updated
2023-05-10
Healthy Volunteers
No
Conditions
Interventions
External beam radiotherapy (EBRT) + High-dose rate (HDR) Brachytherapy Experimental
40 Gy / 15 Fractions EBRT + HDR-Brachytherapy
External beam radiotherapy (EBRT) + High-dose rate (HDR) Brachytherapy Standard of Care
45 Gy / 25 Fractions EBRT + HDR-Brachytherapy
Concurrent Chemotherapy
Weekly cisplatin 40 mg/m2 for a maximum of 5 cycles
Locations (3)
BC Cancer - Kelowna
Kelowna, British Columbia, Canada
London Health Sciences Centre - London Regional Cancer Program
London, Ontario, Canada
Odette Cancer Centre - Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada