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Lung Structure-Function In Survivors of Mild and Severe COVID-19 Infection
Sponsor: Western University, Canada
Summary
This is a longitudinal study of the long-term impact of COVID-19 on the lungs. Participants will be followed over a period of up to 4 years and impacts of COVID-19 on the lungs will be measured with magnetic resonance imaging (MRI) using hyperpolarized xenon-129, pulmonary function tests, exercise capacity, computed tomography imaging and questionnaires.
Official title: Lung Structure-Function In SurVivors of Mild and SEvere COVID-19 Infection: 129Xe MRI and CT For Rapid Evaluations and NExt-wave Healthcare Planning
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
OBSERVATIONAL
Enrollment
100
Start Date
2021-01-01
Completion Date
2026-12-01
Last Updated
2025-08-14
Healthy Volunteers
No
Conditions
Interventions
Hyperpolarized Xenon-129 MRI of the lungs
Participants will be imaged using MRI using hyperpolarized xenon-129 gas as a contrast gas
Computed Tomography (CT)
Participants will undergo a CT scan of the thoracic cavity
Pulmonary Function Tests (PFT)
Participants will have their lung function evaluated using PFT
Six Minute Walk Test (6MWT)
Participants will perform the six minute walk test as a measure of exercise capacity
Sputum analysis
Participants will provide a sputum sample that will be analysed for eosinophils
Blood analysis
Participants will have their blood drawn and analysed for eosinophil count.
Questionnaires
Participants will complete questionnaires to assess activity related dyspnea, respiratory symptoms and health status impairment and respiratory related quality of life.
Locations (1)
Department of Medicine (Respirology), McMaster University
Hamilton, Ontario, Canada