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Molecular Mechanisms of Disease Relapse After Allogenic Stem Cell Transplantation in MDS Patients
Sponsor: Gruppo Italiano Malattie EMatologiche dell'Adulto
Summary
This is a biological study for adult MDS patients who undergo HSCT procedure. Viable bone marrow samples will be collected and cryopreserved from MDS patients before transplantation and at clinical disease recurrence. CD34+ blast cells at disease relapse after HSCT will be compared with CD34+ cells collected before transplant to study genomic and transcriptomic changes.
Official title: Molecular Mechanisms of Disease Relapse After Allogenic Stem Cell Transplantation in Patients With Myelodysplastic Syndrome
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
38
Start Date
2021-02-12
Completion Date
2025-03
Last Updated
2024-10-22
Healthy Volunteers
No
Conditions
Interventions
bone marrow withdrawal
bone marrow samples evaluation
Locations (7)
Aou Consorziale Policlinico - Bari - Uo Ematologia Con Trapianto
Bari, Italy
Unità di Ricerca e di Malattie del sangue - Ematologia S. Luca Vecchio
Florence, Italy
AOU San Martino-IST-Ematologia 1
Genova, Italy
Sezione di Ematologia - Ospedale S.Maria della Misericordia
Perugia, Italy
Dip. di Medicina Trasl. E di Precisione - U.O.C. Ematologia
Roma, Italy
Policlinico Tor Vergata
Roma, Italy
Ististuto Clinico Humanitas - Rozzano - Uo Oncologia Medica Ed Ematologia
Rozzano, Italy