Clinical Research Directory

Myeloid Cells in Patients With Covid-19 Pneumonia

Sponsor: Assistance Publique - Hôpitaux de Paris

Summary

The purpose of this study is to analyze in depth the relationship of myeloid cell subpopulations during infection by Severe acute respiratory syndrome coronavirus 2 (SARS-Cov2), the virus mediating Covid-19. Myeloid cells include neutrophils, monocytes and dendritic cells, each divided into subpopulations with different functions in immune defense and immune pathologies. The study is based on the following hypotheses: * Infection and the interferon response to infection may induce hyperactive or immunosuppressive differentiation of myeloid cells, that may be treated by specific inhibitors. * Some myeloid cell subpopulations currently identified in our laboratories might be markers for Covid-19 prognosis. * Alternative receptors may be present on myeloid cells, inducing the cytokine storm, a target for therapy. * The expression of Interferon (IFN) receptor and IFN responding genes on myeloid cells and on respiratory epithelial cells may correlate with prognosis and indicate potential treatment targets. * Interferon responses are known to be skewed during Covid-19, but some IFN subtype polymorphisms may correlate with prognosis and these subtypes migt be supplemented or inhibited for therapy.

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