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Gut Microbiome and Sex as Risk Factors for Kidney Stones After Bariatric Surgery
Sponsor: University of Chicago
Summary
This is a single-center study that aims to better understand how diet and sex affect the risk of kidney stones in people who have had gastric bypass surgery. Subjects will be asked to follow a special (clinic-provided) diet for six days and come to a research clinic for 3 study visits.
Key Details
Gender
All
Age Range
18 Years - 130 Years
Study Type
INTERVENTIONAL
Enrollment
28
Start Date
2020-11-01
Completion Date
2026-04-01
Last Updated
2025-04-22
Healthy Volunteers
No
Conditions
Interventions
Special diet
The research clinic will provide subjects with a special diet for six days. After six days of isocaloric sodium, calcium and fluid intake, the study team will analyze three sequential 24-hour urine compositions including supersaturation of calcium oxalate, calcium, and urine volume, as well as stool collections. We will also evaluate components of 24-hour urine composition, specifically supersaturation, and the microbial contributions to urinary composition in 72-hour stool samples simultaneously collected using shot-gun metagenomic sequencing in men and women 1 year after surgery.
Locations (1)
University of Chicago Medical Center
Chicago, Illinois, United States