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Excessive Supraventricular Activity and Atrial Fibrillation
Sponsor: Karolinska Institutet
Summary
The aim of the proposed study is to determine if individuals with excessive supraventricular ectopic activity (ESVEA) on Holter recording should be subjected to prolonged screening with Event loop recorder in order to detect previously undiagnosed Atrial fibrillation / flutter. Other biomarkers such as plasma biomarkers, high-end echocardiography and assessment of blood pressure and atrial stiffness will be studied and compared in ESVEA and control group as well as progression of atrial cardiomyopathy in ESVEA patients.
Official title: Detection of Atrial Fibrillation in Patients With Excessive Supraventricular Activity
Key Details
Gender
All
Age Range
70 Years - 89 Years
Study Type
OBSERVATIONAL
Enrollment
250
Start Date
2022-11-01
Completion Date
2028-02-15
Last Updated
2024-03-06
Healthy Volunteers
Yes
Conditions
Interventions
Holter recording
Holter recording with Zenicor Flex ECG during 14 days.
Echocardiography (Echo)
Echocardiography: Comprehensive transthoracic echocardiography with special focus on atrial dimension and function.
Blood sample
Blood sample: 2 x 10 ml EDTA plasma sampled from venous blood at index and at 21 months. Troponin T, NTproBNP, Na, K, Creatinine. Sample for Biobank for future analysis.
24 hour ambulatory blood pressure monitoring And Arteriograph
To assess artery stiffness.
Locations (1)
Danderyd Hospital
Stockholm, Sweden