Clinical Research Directory

Inclusion Criteria: 1. Thai nationality 2. Age 18-40 years old 3. Female-to-Male transgender individual 4. HIV-negative 5. Body mass index 18.5-24.9 kg/m2 6. Negative urine pregnancy test 7. Calculated creatinine clearance (CrCl) ≥60 mL/min, as estimated by the Cockcroft-Gault equation 8. Alanine aminotransferase (ALT) ≤2.5 x ULN 9. Signed the informed consent form Exclusion Criteria: 1. Known history of allergy to hormonal component to be used in the study 2. Use of pre-exposure prophylaxis or post-exposure prophylaxis in the past 30 days 3. Use of injectable MHT in the past 3 months 4. Evidence of current hepatitis B virus infection (HBV) - i.e. hepatitis B surface antigen \[HBsAg\] positive 5. Evidence of current hepatitis C virus infection (HCV) - i.e. HCV antibody positive 6. History of myocardial infarction or coronary artery disease 7. Current use of any of the following: * Anticonvulsants: carbamazepine, oxcarbazepine, phenytoin, or phenobarbital * Herbs: gingko biloba, St John's wort or milk thistle * Anti-infective agents: protease inhibitors, rifampicin or rifabutin 8. History of gastrointestinal tract surgery that alter gastrointestinal tract and/or drug absorption 9. Alcohol or drug use that, in the opinion of the investigator, would interfere with completion of study procedures