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Role of Body Composition in Large for Gestational Age Infants (LGA) With Oral Feeding Difficulty
Sponsor: Nemours Children's Clinic
Summary
Large for Gestational Age (LGA) infants have excess fat-mass (FM) proportion secondary to prolonged in utero exposure to an energy-rich environment. Our preliminary data suggest that excess FM proportion can be associated with oral feeding delay and a potentially modifiable therapeutic target to improve oral feeding outcomes. The objective of this study is to determine the impact of a short-term Fat-free mass (FFM)-indexed feeding on the oral intake volumes in LGA infants with oral feeding difficulties.
Official title: Pilot Randomized Controlled Trial Comparing FFM-indexed Feeding vs. Standard Feeding in LGA Infants With Oral Feeding Difficulty and Disproportionate Body Composition.
Key Details
Gender
All
Age Range
1 Week - 10 Weeks
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2024-09-26
Completion Date
2027-02-28
Last Updated
2025-05-30
Healthy Volunteers
Yes
Interventions
Dietary intervention
energy-restricted diet appropriate for resting metabolic rate using FFM as proxy
Locations (2)
Nemours Children's Hospital
Orlando, Florida, United States
Emory University
Atlanta, Georgia, United States