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The Gut Immune System During Immune Checkpoint Inhibitor Therapy
Sponsor: University Medical Center Groningen
Summary
This exploratory study aims to gain insight in gut immune system phenotypes before and after immunotherapy. After informed consent is obtained, sigmoidoscopies at baseline and during treatment with immunotherapy will be performed, During the endoscopies, biopsies from the sigmoid and rectum will be obtained. Subsequent immune cell analyses in these biopsies will be performed. Parallel to the sigmoidoscopies, venous blood samples will be obtained to monitor inflammatory markers.
Official title: Deep Phenotyping of the Gut Immune System During Immune Checkpoint Inhibitor Therapy - DEFENCE
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
38
Start Date
2021-10-30
Completion Date
2026-06
Last Updated
2025-11-25
Healthy Volunteers
No
Conditions
Interventions
sigmoidoscopies and and venous blood sampling
Sigmoidoscopies will be performed at baseline and during immunotherapy. During these procedures biopsies will be taken from the sigmoid and rectum. At the same timepoints, venous blood samples will be taken.
Locations (1)
University Medical Center Groningen
Groningen, Netherlands