Clinical Research Directory
Browse clinical research sites, groups, and studies.
Molecular and Epidemiological Risk Factors in the Development of Gastric Cancer
Sponsor: The University of Texas Health Science Center at San Antonio
Summary
This protocol is a single-institution feasibility study to identify the molecular and epidemiological risk factors in the development of gastric cancer in high-risk predominantly Hispanic South Texas population. The study is broken down into two main parts: 1) To identify molecular differences in gastric adenocarcinoma (GAC) between Non-Hispanics and Hispanics, stratified by age, and in benign, pre-malignant, and malignant gastric lesions; and 2) To identify environmental and clinicopathological factors in Hispanics associated with specific molecular changes linked to the development of GAC.
Official title: Identification of Molecular and Epidemiological Risk Factors in the Development of Gastric Cancer in High-risk Predominantly Hispanic Population
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
150
Start Date
2021-01-22
Completion Date
2030-01-22
Last Updated
2025-03-18
Healthy Volunteers
No
Conditions
Interventions
Molecular testing for all participants.
Molecular testing on formalin fixed paraffin-embedded (FFPE) tissues on retrospectively identified patients with gastric adenocarcinoma.
Germline Testing
Germline testing will be done on prospectively identified patients and in retrospectively identified patients who are still alive.
Survey
Survey will be administered on prospectively identified patients and in retrospectively identified patients who are still alive. Survey will be administered in person or via telephone. The survey in the language of the participants choice (English or Spanish) on sociodemographic information, current and/or prior PPI (proton pump inhibitor), H2 blocker, antibiotic, tobacco, alcohol, and recreational drug use. Questionnaire will include other risk factors for gastric adenocarcinoma such as certain dietary constituents (high salt diet, high consumption of processed meat, etc.) and occupational exposures.
Locations (1)
Mays Cancer Center, UT Health San Antonio
San Antonio, Texas, United States