Clinical Research Directory

Inclusion Criteria: * Age 18 - 65y inclusive * History or evidence of TBI, according to DoD-VA criteria * Glasgow Coma Scale (GCS) 3 - 15 after resuscitation in the ED * Head CT with evidence of trauma-related abnormality (except for isolated epidural hematoma (EDH)) * Ability to undergo MRI within 48 hours of injury * Ability to obtain informed consent from participant or Legally Authorized Representative (LAR) within 6 hours of injury * Fluency in English or Spanish Exclusion Criteria: * Unstable respiratory or hemodynamic status * Evidence of penetrating brain injury * Isolated EDH as only trauma-related CT abnormality * Systemic traumatic injury that would preclude participation in study, which is expected to result in long-term disability not related to TBI * Evidence of serious infectious complications (sepsis, bacteremia, multilobar pneumonia) * Acute ischemic heart disease (myocardial infarction or unstable angina) * History of syncope or hypotension * Systolic blood pressure (SBP) \< 90 mm Hg, Diastolic blood pressure (DBP)\< 40 mm Hg for longer than 5 minutes * History or evidence of active malignancy * History of pre-existing neurologic disorder, such as dementia, mild cognitive impairment, uncontrolled epilepsy, multiple sclerosis, strokes, brain tumors, prior severe TBI, or other disorder that may confound interpretation of MRI or neuropsychological results * History of pre-existing disabling mental illness, such as major depression or schizophrenia * History or evidence of chronic heart failure or chronic renal failure * Low likelihood of follow-up (e.g., participant or family indicating low interest, residence in another state or country, unhoused or lack of reliable contacts) * Women who are pregnant or breast-feeding * Prisoners or patients in custody * Patients on psychiatric hold (e.g. 5150, 5250)