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Recommendations of Enhanced Recovery Interventions for Patient's Clinical Team and Collection of Associated Data
Sponsor: Jennifer Holder-Murray
Summary
This REMAP Periop ERP domain study falls under the Periop Core Protocol, which compares the different recommended strategies for enhancing recovery through the use of various standard of care treatments before, during and after surgery in all patients with elective surgical encounters at UPMC who meet eligibility criteria. The ERP domain seeks to enhance recovery by optimizing strategies of perioperative care through evaluating combinations of perioperative treatment, which consists of preoperative, intraoperative and postoperative care. Optimal combinations of perioperative care will be generated and analyzed to determine the best outcomes for patients as defined by reduction in hospital free days, reduction in postoperative nausea and vomiting, and improved pain control.
Official title: Randomized, Embedded, Multifactorial Adaptive Platform for Perioperative Medicine at UPMC (UPMC REMAP): Core Protocol - Enhanced Recovery Protocols (ERP)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
3395
Start Date
2023-05-15
Completion Date
2025-03-21
Last Updated
2026-05-28
Healthy Volunteers
No
Conditions
Interventions
Neuraxial Analgesia
This randomized group will receive a neuraxial morphine injection (intrathecal morphine/hydromorphone).
Regional Block 1: Paravertebral
This randomized group will receive regional technique analgesia with sodium channel nerve blockade pharmacotherapy (ie nerve block)
Perphenazine
This randomized group will receive 8 mg of perphenazine orally preoperatively.
Aprepitant
This randomized group will receive 40 mg of aprepitant orally preoperatively.
Dimenhydrinate
This randomized group will receive 25 mg of dimenhydrinate orally preoperatively.
Ondansetron 4 MG
This randomized group will receive 4 mg of ondansetron orally.
Dexamethasone
This randomized group will receive 4-5 mg of dexamethasone intravenously.
Regional Block 2: QL1
This randomized group will receive regional technique analgesia with sodium channel nerve blockade pharmacotherapy (ie nerve block)
Locations (3)
UPMC Magee-Womens Hospital
Pittsburgh, Pennsylvania, United States
UPMC Presbyterian
Pittsburgh, Pennsylvania, United States
UPMC Passavant
Pittsburgh, Pennsylvania, United States