Clinical Research Directory

Inclusion Criteria: * Parent or LAR has signed information consent * Subject weighs between 2.5-10 kg (or 5.5-22 lbs) * Subject is receiving medical care in an intensive care unit * Parental or LAR consent to receive full supportive care through aggressive management utilizing all available therapies for a minimum of 96 hours * Subject has a clinical diagnosis of acute kidney injury per Kidney Disease Improving Global Outcomes (KDIGO) criteria or fluid overload requiring CRRT Exclusion Criteria: * Subject is not expected to survive 72 hours due to an irreversible medical condition, in the opinion of the investigator * Subject has irreversible brain damage, in the opinion of the investigator * Subject is intolerant to anticoagulation, as documented in the medical record * Subject has a Do Not Attempt Resuscitate (DNAR), Allow Natural Death (AND), withdrawal of care or similar order, or anticipated change in status, in the opinion of the investigator, within the next 7 days * Subject has pre-existing end-stage renal disease or pre-existing, advanced chronic kidney disease, defined as an estimated Glomerular Filtration Rate (eGRF) \< 30 ml/min/1.73m2 * Subject is currently or has chronically been treated with a circulatory support device (i.e., left ventricular assist device (LVAD)) other than ECMO * Subject has had prior CRRT treatments using the Carpediem™ system * Subject is enrolled in clinical trials or being treated with other investigational therapeutic devices or products for acute kidney injury or fluid overload * Subject has any other medical condition that may confound the study objectives, in the opinion of the investigator