Clinical Research Directory
Browse clinical research sites, groups, and studies.
Effects of Sulforaphane for Patients With Chronic Kidney Disease
Sponsor: Universidade Federal Fluminense
Summary
Patients with Chronic Kidney Disease (CKD) have many complications associated with inflammation, oxidative stress and intestinal dysbiosis, which are closely related to the progression of kidney failure and cardiovascular disease. Sulforaphane, an isothiocyanate found in cruciferous vegetables (Family: Brassicaceae) is recognized as one of the most important activators of erythroid nuclear factor 2 related to factor 2 (Nrf2). However, clinical evidence to assess the effects of sulforaphane in patients with CKD is scarce, and there are no studies that have investigated its effects on the expression of genes and markers related to inflammation in these patients. Thus, the present project proposes a longitudinal study of the clinical trial type that aims to evaluate the effects of sulforaphane on transcription factors and inflammatory markers in patients with CKD.
Official title: Salutary Effects of Sulforaphane for Patients With Chronic Kidney Disease
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
25
Start Date
2021-12-01
Completion Date
2026-12-31
Last Updated
2025-04-03
Healthy Volunteers
No
Conditions
Interventions
L-sulforaphane 1%
Administration of 4g L-sulforaphane per day, for 2 months
Placebo Group
Administration of 4g corn starch colored with chlorophyll, per day, for 2 months
Locations (1)
Denise Mafra
Rio de Janeiro, Brazil