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Liver Transplantation in Patients With CirrHosis and Severe Acute-on-Chronic Liver Failure: iNdications and outComEs
Sponsor: European Foundation for Study of Chronic Liver Failure
Summary
Management of ACLF is mainly supportive. The poor outcomes lead physicians to consider liver transplantation as an option, even if controversial. In sicker recipients, LT results in immediate survival, but poor medium-term survival rates in some studies. The scarcity of deceased donors obliges to maximize LT success. Alternative strategies, as living-donor LT, should be explored. LDLT has impressive results in Eastern centers, but it is restrained in Western countries, due to potential life-threatening complications in the donor.
Official title: Liver Transplantation in Patients With CirrHosis and Severe Acute-on-Chronic Liver Failure (ACLF): iNdications and outComEs
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
OBSERVATIONAL
Enrollment
3000
Start Date
2021-07-08
Completion Date
2026-12-31
Last Updated
2025-10-20
Healthy Volunteers
Not specified
Conditions
Interventions
Observational Protocol
The cohorts will be followed for one year after LT transplantation except for group 3 (1-year follow-up after inclusion)
Locations (106)
Cedars-Sinai Comprehensive Transplant Center
Los Angeles, California, United States
University of Colorado
Aurora, Colorado, United States
Tampa General Hospital
Tampa, Florida, United States
Piedmont Healthcare
Atlanta, Georgia, United States
Northwestern Memorial Hospital
Chicago, Illinois, United States
The University of Chicago Medicine
Chicago, Illinois, United States
University of Maryland School of Medicine
Baltimore, Maryland, United States
Weill Cornell Medicine
New York, New York, United States
Icahn School of Medicine at Mount Sinai
New York, New York, United States
Montefiore Medical Center
New York, New York, United States
University of Cincinnati
Cincinnati, Ohio, United States
Cleveland Clinic
Cleveland, Ohio, United States
University of Pennsylvania
Philadelphia, Pennsylvania, United States
Vanderbilt University Medical Center
Nashville, Tennessee, United States
Baylor College of Medicine (Scott & White)
Dallas, Texas, United States
Michael E DeBakey VA Medical Center
Houston, Texas, United States
Baylor St. Luke's Medical Centre
Houston, Texas, United States
University of Utah Health
Salt Lake City, Utah, United States
Austral University Hospital
Buenos Aires, Argentina
Hospital Alemán
Buenos Aires, Argentina
Italian Hospital in Buenos Aires
Buenos Aires, Argentina
Austin Hospital
Heidelberg, Australia
Sir Charles Gairdner Hospital
Nedlands, Australia
Royal Prince Alfred Hospital
Sydney, Australia
Medical University of Vienna, Department of Transplant Surgery
Vienna, Austria
CUB Erasme Hospital
Brussels, Belgium
Ghent University Hospital
Ghent, Belgium
UZ Leuven
Leuven, Belgium
Walter Cantídio University Hospital
Fortaleza, Brazil
Irmandade Santa Casa de Misericórdia de Porto Alegre
Porto Alegre, Brazil
Hospital das Clínicas da Universidade de São Paulo
São Paulo, Brazil
University of Alberta
Edmonton, Canada
University of Toronto, Multiorgan Transplant Program
Toronto, Canada
Pablo Tobón Uribe Hospital
Medellín, Colombia
Institute for Clinical and Experimental Medicine
Prague, Czechia
APHP Beaujon
Clichy, France
APHP Henri Mondor
Créteil, France
Hôpital de la Croix-Rousse
Lyon, France
CHU Montpellier-Hôpital Saint Eloi
Montpellier, France
APHP Hôpitaux Universitaires Pitié Salpêtrière
Paris, France
CHU Rennes, Hôpital De Pontchaillou
Rennes, France
Hautepièrre Hospital, Service de Réanimation Médicale
Strasbourg, France
Trousseau Hospital,
Tours, France
Hôpital Paul Brousse
Villejuif, France
University Hospital Regensburg
Regensburg, Eastern Bavaria, Germany
Universitätsklinikum Schleswig-Holstein (UKSH)
Kiel, Schleswig-Holstein, Germany
University Hospital Aachen
Aachen, Germany
Charité University Hospital
Berlin, Germany
Goethe University Clinic
Frankfurt, Germany
University Medical Center, Hamburg Eppendorf
Hamburg, Germany
Hannover Medical School
Hanover, Germany
University Hospital Heidelberg
Heidelberg, Germany
Jena University Hospital
Jena, Germany
Universitätsklinikum Schleswig-Holstein (UKSH)
Kiel, Germany
Leipzig University Hospital
Leipzig, Germany
University Hospital Mainz
Mainz, Germany
LMU Großhadern
Munich, Germany
UKM Muenster
Münster, Germany
University Hospital Tübingen
Tübingen, Germany
Queen Mary Hospital, The University of Hong Kong
Hong Kong, Hong Kong
Aster CMI Hospital
Bengaluru, Karnataka, India
Kasturba Hospital
Mumbai, Maharashtra, India
Seth GSMC & KEM Hospital
Mumbai, Maharashtra, India
Indraprastha Apollo Hospitals
New Delhi, National Capital Territory of Delhi, India
Mahatma Gandhi University of Medical Sciences and Technology
Jaipur, Rajasthan, India
Dr.Rela Institute & Medical Centre
Chennai, India
Fortis Hospital Noida, FEHI, FMRI
Gurugramam, India
Medanta Medicity
Gurugramam, India
Amrita Institute of Medical Sciences
Kochi, India
Global Hospital. Super speciality & transplant centre
Mumbai, India
Max Saket Hospital
New Delhi, India
Yashoda Hospitals
Secunderabad, India
Ospedale Papa Giovanni XXIII-
Bergamo, Italy
S.Orsola Hospital - Alma Mater Studiorum University of Bologna
Bologna, Italy
Ca' Granda. Policlinico Milano
Milan, Italy
Niguarda Hospital
Milan, Italy
University and Hospital of Padova
Padova, Italy
Kyushu University Hospital
Fukuoka, Japan
Hiroshima University Hospital
Hiroshima, Japan
Kyoto University Hospital
Kyoto, Japan
Nagasaki University Hospital
Nagasaki, Japan
Tokyo University Hospital
Tokyo, Japan
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
Mexico City, Mexico
University Medical Center Groningen (UMCG)
Groningen, Netherlands
Erasmus MC University Medical Center
Rotterdam, Netherlands
Auckland City Hospital- New Zealand Liver Transplant Unit
Auckland, New Zealand
Medical University of Warsaw, Dept. of General, Transplant & Liver Surgery
Warsaw, Poland
Hospital Curry Cabral
Lisbon, Portugal
Samsung Medical Center
Seoul, South Korea
Hospital Clinic in Barcelona
Barcelona, Spain
Hospital Vall d'Hebron
Barcelona, Spain
Hospital Universitario 12 de Octubre
Madrid, Spain
Hospital Universitario Ramón y Cajal
Madrid, Spain
Hospital Marqués de Valdecilla
Santander, Spain
Hospital Universitario Virgen del Rocío
Seville, Spain
Hospital Universitari i Politècnic La Fe
Valencia, Spain
Karolinska Institutet
Stockholm, Stockholm County, Sweden
Geneva University Hospital (HUG)
Geneva, Switzerland
Kaohsiung Chang Gung Memorial Hospital
Kaohsiung City, Taiwan
Inonu University, Liver Transplantation Institute
Malatya, Anatolia, Turkey (Türkiye)
Istanbul Memorial Bahcelievler Hospital
Istanbul, Turkey (Türkiye)
Queen Elizabeth Hospital Birmingham
Birmingham, United Kingdom
Scottish Liver Transplant Unit, Royal Infirmary
Edinburgh, United Kingdom
Leeds Teaching Hospitals NHS Trust
Leeds, United Kingdom
King's College Hospital
London, United Kingdom
Royal Free Hospital
London, United Kingdom