Clinical Research Directory

Inclusion Criteria: * Written informed consent must be directly obtained from legally competent participants before any study-related assessment is performed. * Male and female participant age ≥16 years. * Participant has recently started vaping, \>1 and \<5 years weekly use. * 70 participants will be c-cigarette never users. * 70 participants will be former or current c-cigarette users. * 10 asymptomatic age and sex-matched healthy people who have never used e- or c-cigarettes will be controls. Exclusion Criteria: * Participants with contraindications for undergoing an MRI such as participants with MRI-sensitive implants, tattoos with MRI-sensitive dye and severe claustrophobia. * Participant is, in the opinion of the investigator, mentally or legally incapacitated, preventing informed consent from being obtained, or cannot read or understand written material. * Participant unable to perform spirometry or plethysmography maneuvers.