Clinical Research Directory

Inclusion Criteria: * Histologically proven STS of the extremities, above the knee, or trunk following review by our pathologist * Lesions smaller than 15cm in largest dimension * Deemed appropriate for preoperative radiotherapy and conservative surgery following patient assessment by a radiation oncologist and surgical oncologist * Lesion is primary or locally recurrent. Patients who underwent unplanned non-oncological excision ("whoops" procedure) at a referring hospital are NOT eligible * No previous radiation therapy * ECOG 0-2 (or Karnofsky Performance Status ≥ 70) within 60 days prior to registration * Resectable primary lesion with or without distant metastasis * Age ≥ 18 * Patient must be able to provide study-specific informed consent prior to study entry * Patient is available for treatment and follow-up Exclusion Criteria: * Patients who underwent unplanned non-oncological excision ("whoops" procedure) at a referring hospital * Lesions below the knee * Prior or concurrent invasive malignancy (except non-melanomatous skin cancer) or lymphomatous/hematogenous malignancy, unless continually disease free for a minimum of 5 years * Regional lymph node involvement * Previous irradiation to the area to be treated * Other major medical illness deemed to preclude safe administration of protocol treatment or required follow-up