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Personalized Treatment for Patients With Premature Ventricular Beats
Sponsor: Oslo University Hospital
Summary
Frequent premature ventricular beats (PVBs) are common, negatively affects the quality of life for many patients, and can lead to impaired contractile function. Rule-out of structural heart disease is key in the assessment of PVBs. Cardiac MR has a high sensitivity for structural heart disease, but the diagnostic gain from this resource-demanding procedure in the work-up of patients with PVBs is unknown. There is a need to establish the role of MR in the evaluation of patients with PVBs to improve diagnostic efficacy, establish treatment strategies, and promote further research. This project will answer three key questions: 1) What is the diagnostic gain from cardiac MR in patients with PVBs? 2) Is MR the real gold standard to rule-out structural heart disease in patients with PVBs? 3) Can non-invasive heart rate parameters guide the strategy for induction of PVBs during invasive electrophysiological procedures?
Key Details
Gender
All
Age Range
18 Years - 90 Years
Study Type
OBSERVATIONAL
Enrollment
224
Start Date
2020-09-30
Completion Date
2040-07-31
Last Updated
2023-11-02
Healthy Volunteers
No
Conditions
Interventions
Invasive cardiac electrophysiological study and ablation therapy
Invasive cardiac electrophysiological study with cathecholamine provocation and pacing procedures, as well as standard 3D mapping and PVC ablation
Cardiopulmonary exercise testing
Standard ergometer bicycle test
Cardiac MRI
Cardiac MRI with cine-imaging and late-gadolinium enhancement
Holter monitoring
24h 5 lead or 12 lead ECG recording
Transthoracic echocardiography
2D echocardiography
Coronary angiography
Conventional invasive coronary angiography or CT angiography as indicated
Locations (1)
Oslo University Hospital
Oslo, Norway