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A Master Protocol Empowering Mechanobiology Translation Research in Breast Cancer
Sponsor: IFOM ETS - The AIRC Institute of Molecular Oncology
Summary
METAMECH is a master observational protocol designed to empower a bi-directional collaboration between basic and clinical research, an essential prerequisite to feed and implement precision oncology. METAMECH will follow a stage-mixed cohort of at least 500 patients through their course of treatments, until death or a minimum of 5 years. Patients will be longitudinally sampled and matched clinical data (including imaging) will be collected. Via a multi-tiered informed consensus process, METAMECH will also allow to develop companion diagnostics for molecular enrichment strategies in AIRC-driven proof-of-concept trials.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
1500
Start Date
2020-07-16
Completion Date
2026-12
Last Updated
2025-05-01
Healthy Volunteers
No
Conditions
Interventions
Observational
Retrospective cohorts and Prospective observation of standard clinical practice
Locations (10)
Asst Papa Giovanni Xxiii
Bergamo, Bergamo, Italy
Fondazione IRCCS, Istituto Nazionale dei Tumori
Milan, Milan, Italy
Fondazione IRCCS, Istituto Neurologico Carlo Besta
Milan, Milan, Italy
Azienda Ospedaliero Universitaria Maggiore della Carità di Novara
Novara, Novara, Italy
Istituto Oncologico Veneto IRCCS (IOV)
Padova, Padova, Italy
Fondazione IRCCS, Policlinico San Matteo Pavia
Pavia, Pavia, Italy
Istituto Nazionale Tumori Regina Elena di Roma - Istituti Fisioterapici Ospitalieri (IFO)
Roma, Roma, Italy
IRCCS Humanitas
Milan, Italy
IEO - Istituto Europeo di Oncologia
Milan, Italy
Azienda U.S.L. - IRCCS di Reggio Emilia
Reggio Emilia, Italy