Clinical Research Directory

Inclusion Criteria: * Male and females of age between 18 to 85 year of age * History of one-sided ischemic or hemorrhagic stroke * Chronic: more than 6 months post-stroke (Aim 1 and Aim 2) * Subacute: within 8 weeks post-stroke (Aim 1 and Aim 3) * Residual functional impairment of a lower extremity as a result of the stroke * Ability to walk at least 15 meters with or without assistive devices (FIM walk subsection, levels 6 and 7) * Ability to walk 3 consecutive minutes (5 minutes for Aim 2) on a treadmill at a speed equal to or greater than 0.22 m/s (0.8 km/h or 0.5 mph) with or without hand support. * Medical clearance received from treating physician to participate in the gait training program proposed in the study Exclusion Criteria: * Severe aphasia limiting the ability to express needs or discomfort verbally or non-verbally * Cognitive impairment limiting the ability to understand and follow instructions (as assessed by a score \<23 on the Mini Mental State Examination) * Previous diagnosis of neurological diseases other than stroke * Recent history of lower extremity fractures (\<12 months ago), unhealed wounds * Current indication for isolation precautions (e.g. MRSA, VRE, C. difficile, and others) * Severe visual impairments (as assessed by the NIH Stroke Scale Visual Field subscale. score \>0) * Hemispatial neglect (as assessed by the Line Bisection Test) * Subjects diagnosed with a medical condition that would interfere with their participation in regular sustained exercise (such as a severe pulmonary and/or cardiovascular condition) * For Aim 2: currently participating in a gait training intervention (PT or research) * Adults with impaired decision-making capacity * Women who are pregnant