Clinical Research Directory

Inclusion Criteria: * A diagnosis of type 2 diabetes (Patients) * Age between 50-70 years (All) * Presence of CAN as diagnosed by cardiovascular reflex tests with two or three pathological results (Patients with CAN only) * Exclusion of CAN as diagnosed by cardiovascular reflex tests with no pathological results (Patients without CAN and HC only) Exclusion Criteria: * Participants receiving treatment with direct effects on noradrenergic or cholinergic signaling (for example beta-blockers, tricyclic antidepressants, SSRI's) (All) * Acute infections (All) * Thyroid disease (All) * Substance or alcohol abuse (All) * Atrial fibrillation or flutter (All) * Respiratory failure (All) * Participants in active laser treatment for retinopathy, will be excluded from the Valsalva test (Patients) * Non-diabetic causes of neuropathy including a medical history of vitamin B12 deficiency, folic acid deficiency, rheumatoid arthritics, amyloidosis, HIV, syphilis, Borreliosis, drug induced neuropathy and neuropathy caused by toxins (All) * Claustrophobia (All) * Implanted pacemakers or remaining pacemaker electrodes (All) * Previous heart or brain surgery with use of metal clips (All) * Any form of non-MR-compatible implants * Non-compliance with the study protocol as judged by the investigators (All) * Concurrent participation in an intervention study (Patients) * Participants who by judgments of the investigator, is incapable of participating (All)