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Effect of Intraoperative Arterial Oxygen Targets on Thiol-Disulfide Homeostasis and Ischemia-Modified Albumin
Sponsor: Bursa Yuksek Ihtisas Training and Research Hospital
Summary
This single-center randomized trial compared two intraoperative arterial oxygen tension (PaO2) target strategies in adults undergoing elective isolated coronary artery bypass graft surgery. Sixty-four participants were assigned 1:1 to a higher target (PaO2 200 mmHg or greater) or a lower target (PaO2 80 to less than 200 mmHg). The study evaluated perioperative changes in thiol-disulfide homeostasis and ischemia-modified albumin.
Official title: Effects of Two Intraoperative Arterial Oxygen Targets on Thiol-Disulfide Homeostasis and Ischemia-Modified Albumin in Coronary Artery Bypass Graft Surgery
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
64
Start Date
2020-01-01
Completion Date
2020-11-01
Last Updated
2026-09-24
Healthy Volunteers
No
Conditions
Interventions
Intraoperative Oxygenation Strategy: PaO2 200 mmHg or Greater
The fraction of inspired oxygen was actively titrated during anesthesia and cardiopulmonary bypass to achieve an arterial oxygen tension (PaO2) of 200 mmHg or greater. The assigned strategy was maintained intraoperatively, subject to predefined cerebral oxygen saturation safety management.
Intraoperative Oxygenation Strategy: PaO2 80 to Less Than 200 mmHg
The fraction of inspired oxygen was actively titrated during anesthesia and cardiopulmonary bypass to achieve an arterial oxygen tension (PaO2) from 80 to less than 200 mmHg. The assigned strategy was maintained intraoperatively, subject to predefined cerebral oxygen saturation safety management.
Locations (1)
University of Health Sciences Bursa Yüksek İhtisas Training and Research Hospital
Bursa, Bursa, Turkey (Türkiye)