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Bevacizumab Treatment For Type 1 ROP
Sponsor: Jaeb Center for Health Research
Summary
Type 1 retinopathy of prematurity in zone I represents the most severe type of ROP and has the worst prognosis. It is unknown whether low-dose bevacizumab will be successful in these severe cases. Also unknown is the timing and extent of peripheral retinal vascularization after low-dose bevacizumab compared with the standard dose. The current study will evaluate whether doses of 0.063 mg and 0.25mg are effective as treatment for type 1 ROP, with ROP and retinal vessels all in zone I.
Official title: Bevacizumab Treatment For Type 1 Retinopathy of Prematurity
Key Details
Gender
All
Age Range
Any - 6 Months
Study Type
INTERVENTIONAL
Enrollment
77
Start Date
2022-05-01
Completion Date
2027-07-01
Last Updated
2026-02-11
Healthy Volunteers
No
Conditions
Interventions
Bevacizumab
All participants will receive a single intravitreal injection of bevacizumab in one or both eyes following enrollment into the study. The injection/s should be given as soon as possible but no later than 2 days after the diagnosis of type 1 ROP meeting all of the inclusion criteria and none of the exclusion criteria. Eyes meeting eligibility criteria will receive a single dose of 0.063 mg or 0.25mg bevacizumab provided by the pharmacy at the investigator's institution.
Locations (26)
Arkansas Childrens Hospital/ University of Arkansas Medical Sciences
Little Rock, Arkansas, United States
Univ of California, Irvine- Gavin Herbert Eye Institute
Irvine, California, United States
Jules Stein Eye Institute at the University of California, Los Angeles
Los Angeles, California, United States
University of California, Davis
Sacramento, California, United States
University of California San Francisco Department of Ophthalmology
San Francisco, California, United States
The Emory Eye Center
Atlanta, Georgia, United States
Ann & Robert H. Lurie Children's Hospital of Chicago
Chicago, Illinois, United States
U of Illinois at Chicago Eye and Ear Infirmary
Chicago, Illinois, United States
University of Chicago
Hyde Park, Illinois, United States
Indiana University School of Medicine
Indianapolis, Indiana, United States
Riley Hospital for Children
Indianapolis, Indiana, United States
UK Ophthalmology and Visual Sciences, The Eye Clinic
Lexington, Kentucky, United States
Greater Baltimore Medical Center
Baltimore, Maryland, United States
Boston Children's Hospital
Boston, Massachusetts, United States
New York Presbyterian David H Koch Center
New York, New York, United States
Duke University Eye Center
Durham, North Carolina, United States
Cincinnati Children's Hospital
Cincinnati, Ohio, United States
Pediatric Ophthalmology Associates, Inc.
Columbus, Ohio, United States
Casey Eye Institute
Portland, Oregon, United States
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States
UPMC Children's Eye Center of Children's Hospital of Pittsburgh
Pittsburgh, Pennsylvania, United States
Storm Eye Institute
Mt. Pleasant, South Carolina, United States
Texas Children's Hospital - Dept. Of Ophthalmology
Houston, Texas, United States
University of Utah Moran Eye Center
Salt Lake City, Utah, United States
Virginia Pediatric Eye Center
Norfolk, Virginia, United States
IWK Health Centre
Halifax, Nova Scotia, Canada