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Pharmacogenomic Modulators of Impaired Exercise Adaptation in Statin Users
Sponsor: University of Kansas Medical Center
Summary
3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) have beneficial effects (prevent stroke, heart attack) but also some bad ones (block some good effects of exercise). Individuals have genetic variations in proteins that metabolize/transport statins. The investigators hypothesize that these variations modulate the relationship between statin use and lack of benefit from exercise. The investigators will test this by having statin-users do supervised exercise for 6 weeks, measuring the cardiorespiratory fitness before/after and correlating this to genetic variations present in the participant.
Key Details
Gender
All
Age Range
35 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
5
Start Date
2021-06-03
Completion Date
2026-07-30
Last Updated
2025-12-26
Healthy Volunteers
Yes
Conditions
Interventions
Exercise
Patients will exercise on a treadmill three times weekly at approximately 60% VO2max for 30 minutes (week one) followed by 45 minutes (week two and thereafter) for a total of 6 seeks.
Locations (1)
University of Kansas Medical Center
Kansas City, Kansas, United States