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RECRUITING
NCT04637503
PHASE1/PHASE2

4SCAR-T Therapy Targeting GD2, PSMA and CD276 for Treating Neuroblastoma

Sponsor: Shenzhen Geno-Immune Medical Institute

View on ClinicalTrials.gov

Summary

The purpose of this clinical trial is to assess the feasibility, safety and efficacy of multiple 4SCAR-T cell therapy which targets GD2, PSMA and CD276 surface antigens in patients with relapsed and refractory neuroblastoma (NB). Another goal of the study is to understand the function of the multi-CAR-T cells and their persistency in the patients.

Official title: Multi-center Phase I/II Clinical Trial of 4SCAR-T Therapy Targeting GD2, PSMA and CD276 for Treating Neuroblastoma

Key Details

Gender

All

Age Range

1 Year - 65 Years

Study Type

INTERVENTIONAL

Enrollment

100

Start Date

2026-06-01

Completion Date

2030-12-31

Last Updated

2026-06-22

Healthy Volunteers

No

Conditions

Interventions

BIOLOGICAL

GD2, PSMA and CD276 CAR-T cells

infusion, for 1x10\^6\~1x10\^7 cells/kg via IV

Locations (1)

Shenzhen Geno-Immune Medical Institute

Shenzhen, Guangzhou, China