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NMDA Modulation in Major Depressive Disorder
Sponsor: China Medical University Hospital
Summary
Most of the current antidepressants for major depressive disorder (MDD) are based upon the monoamine hypothesis which cannot fully explain the etiology of depression. NMDA hypofunction has been implicated in the pathophysiology of depression. Therefore, this study will examine the efficacy and safety as well as cognitive function improvement of an NMDA enhancer (NMDAE) in the treatment of MDD in the adults.
Key Details
Gender
All
Age Range
18 Years - 55 Years
Study Type
INTERVENTIONAL
Enrollment
90
Start Date
2017-06-01
Completion Date
2026-12
Last Updated
2025-02-19
Healthy Volunteers
No
Conditions
Interventions
NMDAE
Use of an NMDA enhancer for the treatment of MDD
Sertraline
Use of SSRI as an active comparator
Placebo Cap
Use of placebo as a comparator
Locations (1)
Department of Psychiatry, China Medical University Hospital
Taichung, Taiwan