Clinical Research Directory

Inclusion Criteria: * Age ≥18; * Histologically or cytologically confirmed as malignant tumor; * Receiving chemotherapy or a combination of chemotherapy; * The syndrome differentiation of traditional Chinese medicine is the Qi-yin deficiency syndrome; * Sleep disorders were diagnosed by investigators and the Pittsburgh Sleep Quality Index (PSQI) score was ≥ 8; * The date of diagnosis of sleep disorder is later than the date of the first diagnosis of cancer. Or patients with sleep disorders for a long time receiving regular treatment，sleep disorders aggravated after cancer diagnosis or chemotherapy; * Pain has been controlled well \[patients were being treated with analgesics regularly，numerical rating scale（NRS） score ≤ 3\]; * The participant must be able to read and express themselves clearly, can communicate with investigators and cooperate in completing the questionnaire; * Participants voluntarily join the study with good compliance, and are willing to sign a written informed consent document; * Survival period will be longer than 6 months. Exclusion Criteria: * Pregnant or lactating women; * Allergic to Yangzheng Compound Mixture; * Previous diagnosis of sleep apnea; * The laboratory test value of liver and renal function is more than 2.5 times the upper limit of normal value; * Symptoms of brain metastasis due to malignant tumor has not been effectively controlled; * Participating in other drug clinical trials which did not allow to participate in this study; * Refused to cooperate with follow-up; * The researchers did not consider it appropriate for the patients to participate in this study for other reasons.