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Postnatal Steroids Effects on Cardiac Function in Extremely Preterm
Sponsor: McGill University Health Centre/Research Institute of the McGill University Health Centre
Summary
Hypothesis/Study question In infants born at less than 29 weeks of estimated gestational age, what are the effects of dexamethasone use on cardiac structure/performance and lung water content? Study objectives To measure effects before and after dexamethasone administration on cardiac structure/performance will be evaluated by using the M-mode technique (Devereux method (25-27) and lung water content will be specifically determined by the degree of water retention in premature lungs assessed by lung ultrasound at the pre specified time points. Methodology / Study design Single center, prospective observational cohort study planning to enroll eligible patients over a period of 12 months
Official title: "Surveillance of Postnatal Steroids Effects on Cardiac Function in Extremely Preterm Infants With Evolving BPD: the SPEC Study."
Key Details
Gender
All
Age Range
1 Minute - Any
Study Type
OBSERVATIONAL
Enrollment
21
Start Date
2021-06-15
Completion Date
2026-06
Last Updated
2025-06-17
Healthy Volunteers
No
Conditions
Interventions
Echocardiography (ECHO) and lung ultrasound (LUS) studies before and after Dexamethasone administration
A. Electrocardiographic (ECG) leads will be place in the patient for electrocardiogram (ECG) recordings. B. Echocardiography (ECHO) will be performed by an expert member of the Neonatal Echocardiography team C. Heart Rate Variability (HRV): ECG recordings D. Growth trajectory: body weight, length, head circumference, length/weight ratio at 1-, 2-weeks prior treatment, 1-, 2-, 3-, 4-,6-,8-weeks after treatment, at 36-week PMA.
Locations (1)
Montreal Children's hospital, Mcgill University Health Centre
Montreal, Quebec, Canada