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Localizing Epileptic Networks Using MRI and iEEG
Sponsor: University of Pennsylvania
Summary
Upon successful completion of this study, the investigators expect the study's contribution to be the development of noninvasive imaging biomarkers to predict IEEG functional dynamics and epilepsy surgical outcomes. Findings from the present study may inform current and new therapies to map and alter seizure spread, and pave the way for less invasive, better- targeted, patient-specific interventions with improved surgical outcomes. This research is relevant to public health because over 20 million people worldwide suffer from focal drug-resistant epilepsy and are potential candidates for cure with epilepsy surgical interventions.
Official title: Optimized Intracranial EEG Targeting in Focal Epilepsy Based Upon Neuroimaging Connectomics
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
290
Start Date
2021-03-01
Completion Date
2027-02-28
Last Updated
2026-02-13
Healthy Volunteers
Yes
Interventions
3T Magnetic Resonance Imaging
Magnetic resonance imaging acquired at a field strength of 3 Tesla.
Intracranial electroencephalography recordings
Epilepsy patients may undergo implantation of intracranial electroencephalography (iEEG) electrodes for localization of epileptogenic foci, which also provide a means to record localized brain activity during memory or other tasks for research purposes.
7T Magnetic Resonance Imaging
Magnetic resonance imaging acquired at a field strength of 7 Tesla.
Locations (1)
University of Pennsylvania
Philadelphia, Pennsylvania, United States