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RECRUITING
NCT04657042

4D-MRI for Precision Medicine

Sponsor: University of Virginia

View on ClinicalTrials.gov

Summary

The purpose of this study is to develop new ways to make medical images of the lungs and liver of adults using a technique called four-dimensional magnetic resonance imaging (4D-MRI). This technique produces three-dimensional movies of the inside of the chest and abdomen while the patient is breathing. (The fourth dimension is time!) This new way of medical imaging is being developed to help cancer patients undergoing radiation therapy. Radiation therapy is used to treat cancerous tumors. For radiation therapy to be effective, the precise size, shape, and location of the tumor within the body must be known. A particular difficulty for radiation treatment of lung and liver cancer is that the tumor moves during treatment because the patient is breathing. Therefore, tumor motion must also be incorporated into the treatment plan. This study aims to improve radiation treatment planning through better targeting and dose estimation based on 4D-MRI. Before this new imaging method can be used for radiation treatment planning, it must be tested in living, breathing volunteers.

Official title: Toward Precision Radiotherapy: Physiological Modeling of Respiratory Motion Based on Ultra-quality 4D-MRI

Key Details

Gender

All

Age Range

18 Years - 82 Years

Study Type

OBSERVATIONAL

Enrollment

100

Start Date

2020-11-05

Completion Date

2030-12-31

Last Updated

2025-03-24

Healthy Volunteers

Yes

Interventions

DIAGNOSTIC_TEST

Magnetic Resonance Imaging

Four-dimensional MRI of torso

Locations (1)

University of Virginia

Charlottesville, Virginia, United States