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Brief, High-dose rTMS for Depression
Sponsor: Medical University of South Carolina
Summary
High frequency repetitive transcranial magnetic stimulation (rTMS) has been shown to be safe, feasible, and acceptable. Conventionally, rTMS investigations have relied on rational decision trees for dosage determination. The purpose of this study is to systematically examine an accelerated protocol of intermittent theta burst (iTBS). Study 1 aims to provide a quantifiable dose-response curve for iTBS and depressive symptom reduction in major depression. Study 2 aims to determine the role of individual variations of their functional networks compared to the site of stimulation and clinical outcomes.
Official title: Accelerated Repetitive TMS for Affective Dysfunction: Establishing the Dose-Response Curve
Key Details
Gender
All
Age Range
18 Years - 60 Years
Study Type
INTERVENTIONAL
Enrollment
70
Start Date
2021-05-25
Completion Date
2026-12-01
Last Updated
2026-04-02
Healthy Volunteers
Yes
Conditions
Interventions
Repetitive Transcranial Magnetic Stimulation (rTMS)
MagVenture MagPro TMS System would be utilized to deliver 3-minute sessions of intermittent theta burst to left dorsolateral prefrontal cortex.
Locations (1)
Medical University of South Carolina
Charleston, South Carolina, United States