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ACTIVE NOT RECRUITING
NCT04657432
NA

Brief, High-dose rTMS for Depression

Sponsor: Medical University of South Carolina

View on ClinicalTrials.gov

Summary

High frequency repetitive transcranial magnetic stimulation (rTMS) has been shown to be safe, feasible, and acceptable. Conventionally, rTMS investigations have relied on rational decision trees for dosage determination. The purpose of this study is to systematically examine an accelerated protocol of intermittent theta burst (iTBS). Study 1 aims to provide a quantifiable dose-response curve for iTBS and depressive symptom reduction in major depression. Study 2 aims to determine the role of individual variations of their functional networks compared to the site of stimulation and clinical outcomes.

Official title: Accelerated Repetitive TMS for Affective Dysfunction: Establishing the Dose-Response Curve

Key Details

Gender

All

Age Range

18 Years - 60 Years

Study Type

INTERVENTIONAL

Enrollment

70

Start Date

2021-05-25

Completion Date

2026-12-01

Last Updated

2026-04-02

Healthy Volunteers

Yes

Interventions

DEVICE

Repetitive Transcranial Magnetic Stimulation (rTMS)

MagVenture MagPro TMS System would be utilized to deliver 3-minute sessions of intermittent theta burst to left dorsolateral prefrontal cortex.

Locations (1)

Medical University of South Carolina

Charleston, South Carolina, United States