Clinical Research Directory

Inclusion Criteria: * Age ≥ 18 years and ≤ 75 years. * Non-valvular symptomatic persistent atrial fibrillation. * Patient willingness to participate in the study providing signed written informed consent. * Failure or drug intolerance or refusal to continue with chronic antiarrhythmic treatment. * Left ventricular ejection fraction LVEF) ≥ 25 % in the last echocardiogram prior to enrollment. Exclusion Criteria: * Left atrial diameter \> 5.5 cm in the last echocardiogram. * Contraindication of chronic anticoagulation or heparin. * Previous atrial fibrillation ablation procedure. * Acute coronary syndrome, cardiac surgery or acute cerebrovascular accident in two months prior to enrollement. * Previous diagnosis for hyperthyroidism or hypothyroidism. * Mental or physical illness that disables the patient to participate in the study. * Scheduled cardiac percutaneous or surgical intervention. * Non-controlled hypertension \> 160/100. * Terminal renal insufficiency or dialysis. * Functional class IV of the New York Heart Association (NYHA). * Moderate valvular disease or previous mitral prosthesis. * Previous hypertrophic heart disease. * Life expectancy less than 12 months. * Inclusion on the transplant list. * Participation in another study so as not to interfere with the results. * Previous atrioventricular block. * Pericardial effusion. * Pregnancy or childbearing age without contraceptive treatment.