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ACTIVE NOT RECRUITING
NCT04662879
NA

Early Detection Initiative for Pancreatic Cancer

Sponsor: Pancreatic Cancer Action Network

View on ClinicalTrials.gov

Summary

The Early Detection Initiative for Pancreatic Cancer is a multi-center prospective study to determine if algorithm-based screening in patients with glycemically defined new onset hyperglycemia and diabetes has the potential for earlier detection of pancreatic ductal adenocarcinoma.

Official title: A Prospective Study of Algorithm-based Screening in Patients With Glycemically Defined New Onset Diabetes to Evaluate Risk for and Earlier Detection of Pancreatic Ductal Adenocarcinoma; Early Detection Initiative (EDI) for Pancreatic Cancer

Key Details

Gender

All

Age Range

50 Years - 85 Years

Study Type

INTERVENTIONAL

Enrollment

8869

Start Date

2021-10-14

Completion Date

2028-01

Last Updated

2026-03-12

Healthy Volunteers

No

Interventions

OTHER

Enriching New-onset Diabetes for Pancreatic Cancer (ENDPAC) score

ENDPAC is a model to risk-stratify patients with new onset diabetes and hyperglycemia for PDAC. Score is calculated using i) age, ii) change, over past year, in body weight and iii) change, over past year, in glucose/HbA1c values obtained from the electronic medical record.

OTHER

Abdominal imaging

Using computerized tomography (CT) scan or magnetic resonance imaging (MRI), if CT scan is contra-indicated, patients with a high ENDPAC score (\>0) are approached for informed consent to participate in the imaging intervention. Imaging (CT scan) is performed at up to two time points, study baseline and approximately 3-9 months following the first imaging study.

Locations (2)

Kaiser Permanente Southern California, Kaiser Permanente Research

Pasadena, California, United States

Baylor College of Medicine

Houston, Texas, United States