Clinical Research Directory

Inclusion Criteria: * Ages 18 years and older * Meets Diagnostic and Statistical Manual edition 5 (DSM-5) criteria for Major Depressive Disorder (MDD) (as documented by the treating physician) * Meet study criteria for pharmacoresistance in accordance with the Clinical transcranial magnetic stimulation (TMS) Program (i.e. failed at least one antidepressant in the current episode) * Ability to obtain a motor threshold (MT) prior to the start of treatment * Stable medical conditions and ability to maintain stability on current medication regimen for the duration of treatment * Ability to participate in a daily treatment regimen * Able to read, verbalize understanding, and voluntarily sign the Informed Consent Form prior to participating in any study-specific procedures or assessments Exclusion Criteria: * History of seizure disorder * Structural or neurologic abnormalities present or in close proximity to the treatment site * History of brain surgery * Pacemaker or medical infusion device (unless magnetic resonance imaging compatible) * History of traumatic brain injury within 60 days of the start of treatment * Severe or uncontrolled alcohol or substance use disorders * Active withdrawal from alcohol or substances * Implanted device in the head * Metal in the head * Severe impediment to vision, hearing and/or hand movement, likely to interfere with ability to complete the assessments, or unable and/or unlikely to follow the study protocols * Lifetime history of bipolar I disorder * Inability to speak, read or understand English * Plans to move out of the area during the study period * Clinician and/or Investigator discretion for clinical safety or protocol adherence