Clinical Research Directory

Oral Isotretinoin and Covid-19 Infection

Sponsor: University of Aberdeen

Summary

There is a theoretical risk that the nasal mucosal dryness caused by oral retinoid medications may increase risk of infection with Covid-19. Isotretinoin arrests the cell cycle of mucus secreting cells in the nasal cavity, and cilia and mucus are both believed to have roles in defence against infection and immunity. Hence it was postulated at the start of the pandemic that isotretinoin may increase the likelihood of contracting a disease spread by droplet or aerosol particles. The investigators planned to compare rates of infection and deterioration between our group of patients taking isotretinoin, aged 16-40years, and the local (NHS Grampian / Moray) age-matched population.

Official title: Does Oral Isotretinoin Increase the Risk of Developing Infection With and Complications From Covid-19, Compared to an Age-matched Background Population

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