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Integrated Diagnostics for Early Diagnosis of Liver Disease
Sponsor: Manchester University NHS Foundation Trust
Summary
This is an observational study that will explore the hypothesis that by combining data from patients with liver disease with novel blood biomarkers, single nucleotide polymorphism (SNP) analysis and faecal microbiome analysis. The Investigators will improve diagnosis of liver fibrosis compared to the current available diagnostic tools.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
1200
Start Date
2020-10-21
Completion Date
2027-03-31
Last Updated
2026-02-09
Healthy Volunteers
No
Conditions
Interventions
Blood tests for Single Nucleotide Polymorphisms
This extra test would be performed on participants assessed in the specialist liver clinic. This test would require an extra 5ml of blood to be taken at the time of routine blood tests for clinical purposes.
Faecal microbiome analysis
This test will be undertaken for all participants who give consent and are assessed through the new liver care pathway, in the community liver assessment clinic. All participants will be given the equipment to take a stool sample at the time of presentation at the community liver assessment clinic and asked to return the sample to the clinic. The sample will be processed to remove genetic material so the microbiome can be identified.
Serum for diagnostic biomarkers
Blood samples will be taken alongside blood taken for clinical assessment. In total, an extra 5ml of blood. These samples will be used to explore novel blood biomarkers using ELISA and mass-spectroscopy techniques in the University of Manchester.
Locations (1)
Manchester University NHS Foundation Trust
Manchester, Greater Manchester, United Kingdom