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ALI Post Radiation Therapy in Patients With Lung and Esophageal Canter
Sponsor: M.D. Anderson Cancer Center
Summary
The goal of this clinical research study is to learn if giving autologous lymphocyte infusions to patients who are receiving chemotherapy and radiation for non-small cell lung cancer or esophageal cancer is safe and effective.
Official title: Phase II Study of Autologous Lymphocyte Infusions After Radiation Therapy to Mitigate Radiation Induced Lymphopenia and Enhance Immune Reconstitution in Patients With Solid Tumor Malignancies
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
19
Start Date
2020-09-29
Completion Date
2025-10-24
Last Updated
2026-05-07
Healthy Volunteers
Yes
Conditions
Interventions
Autologous lymphocyte infusion (ALI)
On the day after completing the last dose of radiation therapy, the patient will have an appointment scheduled in the Apheresis Unit for the infusion of unmunipulated cryopreserved cells. Patients will be pre medicated with acetaminophen (325-650 mg PO) and diphenhydramine (12.5-25 mg PO or IV) prior to infusion. Cells will be infused without a leukoreduction filter at a rate determined by cell volume.
Locations (1)
M D Anderson Cancer Center
Houston, Texas, United States