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RECRUITING
NCT04676802
PHASE2

Pain Relief After Trapeziectomy: Ibuprofen & Acetaminophen Versus Oxycodone

Sponsor: Stanford University

View on ClinicalTrials.gov

Summary

In the US, pain management after surgery for surgical treatment of osteoarthritis at the base of the thumb typically consists of prescription opioids during the early recovery phase. Given the highly addictive nature of prescription opioids, guidelines are being evaluated by hand surgeons to reduce opioid use while still maintaining pain control after surgery. A promising approach is to use non-narcotic medication as the first line of treatment. The purpose of this study is to demonstrate the efficacy of a combination of non-steroidal anti-inflammatory drugs (NSAIDs), ibuprofen and acetaminophen, in comparison to a morphine analogue substance (oxycodone) for pain management in the first 30 days after surgery.

Official title: Pain Relief After Trapeziectomy Without Opioids: Ibuprofen & Acetaminophen Versus Oxycodone

Key Details

Gender

All

Age Range

45 Years - Any

Study Type

INTERVENTIONAL

Enrollment

121

Start Date

2021-12-27

Completion Date

2027-08

Last Updated

2025-08-06

Healthy Volunteers

No

Interventions

DRUG

NSAID capsules

1, Ibuprofen 400-mg and 1, Acetaminophen 500-mg capsule per dosage

DRUG

Opioid capsule

1, Oxycodone 5-mg capsule and 1, placebo capsule per dosage

Locations (2)

Stanford Health Care

Redwood City, California, United States

University of Utah Health Care

Salt Lake City, Utah, United States